Sistimi ea Phano ea Lithethefatsi (Lipids, Polymers, Hybrids)
Re Theha Mefuta e sa tšoaneng ea Tšebelisano ka Sehlopha sa Rōna le Theknoloji, 'me re Etsa Lithuto tse Felletseng le Tse Kopanetsoeng Ho Kenyeletsoa Lipatlisiso Tse Etsang: Nts'etsopele ea Sistimi ea Phano ea Lithethefatsi ka li-API tse lakatsehang joalo ka mRNA, DNA, siRNA, Antibodies, Protein, Peptides le Limolek'hule Tse Nyenyane: Tlhabollo, le Litšebeletso tsa Teko, K'hamphani e Kopanetsoeng le Lintlafatso tse Tšehetsoeng ke 'Muso (ke hore, SBIR/STTR)
Tlhahlobo ea Analytical, Characterization, Assay Development
Teko e Felletseng ea Tlhahlobo ea Tloaelo (GMP le Non-GMP) le Mekhoa e ntlafalitsoeng bakeng sa Nts'etsopele ea Mehato ea Pele ea Lithethefatsi, Tlhahlobo ea Tlhahlobo, Nts'etsopele le Phetiso ea Theknoloji, Tsoelo-pele e Felletseng ea Tlhahlobo le Litlhahlobo tse kang: Nanoparticle Size, Charge, Encapsulation Efficiency, Purity, Morphology, Residual Solvent, Transition Temperature, Visual Inspections, le Microscopic.
Ntlafatso ea Tlhahiso ea Preclinical le lisampole
Lithuto tse ka khonehang le tse Felletseng, Nts'etsopele ea Sistimi ea Phano ea Lithethefatsi ea Nanoparticle (Preclinical Synthesis le Analytics), Ho kenyelletsa Ionizable le Cationic Lipid Nanoparticles hammoho le Polymeric le Hybrid Lipid Nanoparticles, Optimization, Characterization, Chefo, Katleho, Mekhoa ea Tlhahlobo, Mekhoa e Nyenyane ea Ho Etsa Lintho Theknoloji TransferPreclinical Formulation Synthesis, Optimization, Production Process, Litsamaiso tsa Phano ea Lithethefatsi le Nts'etsopele ea Nanomedicines
Ntlafatso ea Ts'ebetso ea Tlhahiso (GMP)
T&T Scientific E Fana ka Mefuta e sa Tšoaneng 'me Ha e le hantle Mekhoa eohle ea Tlhahiso e Sebelisitsoeng ho Etsa Lihlahisoa tsa Lithethefatsi tsa Nanoparticle tse kang Gene Therapies, le Vaccines. Ho Bolela. Tse 'maloa Mehato ena e kenyeletsa: Ethanol Injection kapa Solvent Injection, Thin Film Hydration, Extrusion, Homogenization, Microfluidics le Sonication (Bath, Tip le Continuous).
Ntlafatso ea Mekhoa ea Tlhahlobo (Phanele e Felletseng, Sebopeho, Tlaleho)
Ho T&T Scientific, Re fana ka Panel e Felletseng le e Feletseng ea cGMP Analytical Panel e Hlokehang bakeng sa Taolo ea Boleng ba Lihlahisoa tsa Lithethefatsi tsa Nanoparticle tse kang: Nanoparticle Size, Charge, Encapsulation Efficiency, Purity, Morphology, Residual Solvent, Transition Temperature, Visual Inspections, Targeting le Endosomal Thepa le Microscopic. Hape re Thehile Balekane Bakeng sa Liteko tsa Clinical le Lithuto tsa Liphoofolo.
cGMP Clinical and Commercial Batch Manufacturing, Tlatsa le Qetella
T&T Scientific E Felletse Ts'ebetso ea GMP Tlas'a Mohaho o le Mong 'me E hlahlobiloe ka Katleho Ka makhetlo a 5. Sistimi ea Tsamaiso ea Boleng ea T&T Scientific Corporation e nka tataiso ho tsoa ho 21 CFR Karolo ea 820 ea Melao ea Tsamaiso ea Boleng mme e latela litlhoko tsohle tsa taolo ea FDA GMP. Litlhoko tsena li kenyelletsa 21 CFR Karolo ea 210, 21 CFR Karolo ea 211, le 21 CFR Karolo ea 11. Khampani ha e tseka ho qheleloa ka thoko ho 21 CFR Karolo ea 820, 201, 211, 11 ho 7140 Regal Lane, Knoxville, TN 37918.
Theknoloji ea Tlhahiso ea Solvent Manufacturing
Solvent Ente Technologies Ke Ente ea Tharollo ea Lipid (Ka Ethanol Kapa Diethyl Ether) Ka Mekhahlelong e Metsi Ho Kenyelletsoa Lithethefatsi le Buffer. Mekhoa ea Ente ea Solvent e kenyelletsa ho qhibiliha ha Lipid ho Sehlahisoa sa Organic le ho Enteloa Tharollo Mokhahlelong oa Mokelikeli. Li-solvents tse peli tse ka sehloohong (Ethanol le Ether) li hiriloe molemong oa Tokiso ea Liposomal Nanoformulation. T&T Scientific E Fana ka Sethala se Molemohali sa Lefatše bakeng sa Scalable, GMP, Controlled and Precipe Production of Nanoparticle Drug Products ka Mohato o le Mong.
Liposome Extrusion Manufacturing Technologies
Liposome Extrusion Techniques li sebelisoa bakeng sa Sizing Lipid Nanoparticles ka ho nepahetseng, Liposomes, Lipoplexes, Niosomes le Lihlahisoa tse ling tsa Nano-scale Pharmaceutical Drug and Drug Delivery Systems. T&T Scientific E Fana ka Mokhoa oa Pele oa Lefatše oa Tšebeliso e le 'Ngoe ea Lipid le Liposome Extrusion System e Lumellang Tlhahiso e Potlakileng, e Bonolo, e sa Silafalang, le ea boleng bo holimo ea Lihlahisoa tsena tsa Lithethefatsi tsa Nanomedicine tse nang le PDI tse tlase ho 0.05-0.07
Sistimi ea Phano ea Lithethefatsi (Lipids, Polymer, Hybrids)
T&T Scientific e fana ka bobeli: 1) Lihlahisoa tse Itokiselitseng ho Sebelisa le Kits joalo ka Lipids, Polymers le Hybrid Nanoparticles 2) Tlas'a Nts'etsopele le Bohlokoa ba Nanoparticles e entsoeng ke Lipids (Cationic, Ionizable, le Neutral), Polymers, le Hybrid e Kenyelletsang Mefuta e sa tšoaneng ea Lipids le Polymers.
CDMO e Kenyelletsang Tsohle le Sethala sa Theknoloji
bakeng sa Mekhoa ea Phano ea Lithethefatsi & Nanomedicines
CDMO e ngolisitsoeng ke FDA
Sistimi ea Taolo ea Boleng ea elektroniki ea cGMP E lumellana le Federal Regulation 21 CFR Karolo ea 210, 211, le 21, 11 bakeng sa Nts'etsopele ea Meriana le Manufacturing
Theknoloji ea Tlhahiso Laboratori le GMP
Fully Integrated Automated with Bohlale ba Maiketsetso le Matla a ho Ithuta ka Mechini
Phetolelo ea Meriana ho tloha Lab ho ea ho Bakuli ba Tšusumetso
Sistimi ea Phano ea Lithethefatsi (Lipids, Polymers, Hybrids)
Re Theha Mefuta e sa tšoaneng ea Tšebelisano ka Sehlopha sa Rōna le Theknoloji, 'me re Etsa Lithuto tse Felletseng le Tse Kopanetsoeng Ho Kenyeletsoa Lipatlisiso Tse Etsang: Nts'etsopele ea Sistimi ea Phano ea Lithethefatsi ka li-API tse lakatsehang joalo ka mRNA, DNA, siRNA, Antibodies, Protein, Peptides le Limolek'hule Tse Nyenyane: Tlhabollo, le Litšebeletso tsa Teko, K'hamphani e Kopanetsoeng le Lintlafatso tse Tšehetsoeng ke 'Muso (ke hore, SBIR/STTR)
Tlhahlobo ea Analytical, Characterization, Assay Development
Teko e Felletseng ea Tlhahlobo ea Tloaelo (GMP le Non-GMP) le Mekhoa e ntlafalitsoeng bakeng sa Nts'etsopele ea Mehato ea Pele ea Lithethefatsi, Tlhahlobo ea Tlhahlobo, Nts'etsopele le Phetiso ea Theknoloji, Tsoelo-pele e Felletseng ea Tlhahlobo le Litlhahlobo tse kang: Nanoparticle Size, Charge, Encapsulation Efficiency, Purity, Morphology, Residual Solvent, Transition Temperature, Visual Inspections, le Microscopic.
Ntlafatso ea Tlhahiso ea Preclinical le lisampole
Lithuto tse ka khonehang le tse Felletseng, Nts'etsopele ea Sistimi ea Phano ea Lithethefatsi ea Nanoparticle (Preclinical Synthesis le Analytics), Ho kenyelletsa Ionizable le Cationic Lipid Nanoparticles hammoho le Polymeric le Hybrid Lipid Nanoparticles, Optimization, Characterization, Chefo, Katleho, Mekhoa ea Tlhahlobo, Mekhoa e Nyenyane ea Ho Etsa Lintho Theknoloji TransferPreclinical Formulation Synthesis, Optimization, Production Process, Litsamaiso tsa Phano ea Lithethefatsi le Nts'etsopele ea Nanomedicines
Ntlafatso ea Ts'ebetso ea Tlhahiso (GMP)
T&T Scientific E Fana ka Mefuta e sa Tšoaneng 'me Ha e le hantle Mekhoa eohle ea Tlhahiso e Sebelisitsoeng ho Etsa Lihlahisoa tsa Lithethefatsi tsa Nanoparticle tse kang Gene Therapies, le Vaccines. Ho Bolela. Tse 'maloa Mehato ena e kenyeletsa: Ethanol Injection kapa Solvent Injection, Thin Film Hydration, Extrusion, Homogenization, Microfluidics le Sonication (Bath, Tip le Continuous).
Ntlafatso ea Mekhoa ea Tlhahlobo (Phanele e Felletseng, Sebopeho, Tlaleho)
Ho T&T Scientific, Re fana ka Panel e Felletseng le e Feletseng ea cGMP Analytical Panel e Hlokehang bakeng sa Taolo ea Boleng ba Lihlahisoa tsa Lithethefatsi tsa Nanoparticle tse kang: Nanoparticle Size, Charge, Encapsulation Efficiency, Purity, Morphology, Residual Solvent, Transition Temperature, Visual Inspections, Targeting le Endosomal Thepa le Microscopic. Hape re Thehile Balekane Bakeng sa Liteko tsa Clinical le Lithuto tsa Liphoofolo.
cGMP Clinical and Commercial Batch Manufacturing, Tlatsa le Qetella
T&T Scientific E Felletse Ts'ebetso ea GMP Tlas'a Mohaho o le Mong 'me E hlahlobiloe ka Katleho Ka makhetlo a 5. Sistimi ea Tsamaiso ea Boleng ea T&T Scientific Corporation e nka tataiso ho tsoa ho 21 CFR Karolo ea 820 ea Melao ea Tsamaiso ea Boleng mme e latela litlhoko tsohle tsa taolo ea FDA GMP. Litlhoko tsena li kenyelletsa 21 CFR Karolo ea 210, 21 CFR Karolo ea 211, le 21 CFR Karolo ea 11. Khampani ha e tseka ho qheleloa ka thoko ho 21 CFR Karolo ea 820, 201, 211, 11 ho 7140 Regal Lane, Knoxville, TN 37918.
Theknoloji ea Tlhahiso ea Solvent Manufacturing
Solvent Ente Technologies Ke Ente ea Tharollo ea Lipid (Ka Ethanol Kapa Diethyl Ether) Ka Mekhahlelong e Metsi Ho Kenyelletsoa Lithethefatsi le Buffer. Mekhoa ea Ente ea Solvent e kenyelletsa ho qhibiliha ha Lipid ho Sehlahisoa sa Organic le ho Enteloa Tharollo Mokhahlelong oa Mokelikeli. Li-solvents tse peli tse ka sehloohong (Ethanol le Ether) li hiriloe molemong oa Tokiso ea Liposomal Nanoformulation. T&T Scientific E Fana ka Sethala se Molemohali sa Lefatše bakeng sa Scalable, GMP, Controlled and Precipe Production of Nanoparticle Drug Products ka Mohato o le Mong.
Liposome Extrusion Manufacturing Technologies
Liposome Extrusion Techniques li sebelisoa bakeng sa Sizing Lipid Nanoparticles ka ho nepahetseng, Liposomes, Lipoplexes, Niosomes le Lihlahisoa tse ling tsa Nano-scale Pharmaceutical Drug and Drug Delivery Systems. T&T Scientific E Fana ka Mokhoa oa Pele oa Lefatše oa Tšebeliso e le 'Ngoe ea Lipid le Liposome Extrusion System e Lumellang Tlhahiso e Potlakileng, e Bonolo, e sa Silafalang, le ea boleng bo holimo ea Lihlahisoa tsena tsa Lithethefatsi tsa Nanomedicine tse nang le PDI tse tlase ho 0.05-0.07
Sistimi ea Phano ea Lithethefatsi (Lipids, Polymer, Hybrids)
T&T Scientific e fana ka bobeli: 1) Lihlahisoa tse Itokiselitseng ho Sebelisa le Kits joalo ka Lipids, Polymers le Hybrid Nanoparticles 2) Tlas'a Nts'etsopele le Bohlokoa ba Nanoparticles e entsoeng ke Lipids (Cationic, Ionizable, le Neutral), Polymers, le Hybrid e Kenyelletsang Mefuta e sa tšoaneng ea Lipids le Polymers.
CDMO e Kenyelletsang Tsohle le Sethala sa Theknoloji
bakeng sa Litsamaiso tsa Phano ea Lithethefatsi & Nanomedicines
CDMO e ngolisitsoeng ke FDA
Electronic cGMP Quality Management System e Lumellanang le Federal Regulation 21 CFR Karolo 210, 211, le 21, 11 bakeng sa Ntlafatso ea Meriana le Manufacturing
Theknoloji ea Tlhahiso Laboratori le GMP
Fully Integrated Automated with Bohlale ba Maiketsetso le Matla a ho Ithuta ka Mechini
Phetolelo ea Meriana ho tloha Lab ho ea ho Bakuli ba Tšusumetso
Sistimi ea Phano ea Lithethefatsi (Lipids, Polymers, Hybrids)
Re Theha Mefuta e sa tšoaneng ea Tšebelisano ka Sehlopha sa Rōna le Theknoloji, 'me re Etsa Lithuto tse Felletseng le Tse Kopanetsoeng Ho Kenyeletsoa Lipatlisiso Tse Etsang: Nts'etsopele ea Sistimi ea Phano ea Lithethefatsi ka li-API tse lakatsehang joalo ka mRNA, DNA, siRNA, Antibodies, Protein, Peptides le Limolek'hule Tse Nyenyane: Tlhabollo, le Litšebeletso tsa Teko, K'hamphani e Kopanetsoeng le Lintlafatso tse Tšehetsoeng ke 'Muso (ke hore, SBIR/STTR)
Tlhahlobo ea Analytical, Characterization, Assay Development
Teko e Felletseng ea Tlhahlobo ea Tloaelo (GMP le Non-GMP) le Mekhoa e ntlafalitsoeng bakeng sa Nts'etsopele ea Mehato ea Pele ea Lithethefatsi, Tlhahlobo ea Tlhahlobo, Nts'etsopele le Phetiso ea Theknoloji, Tsoelo-pele e Felletseng ea Tlhahlobo le Litlhahlobo tse kang: Nanoparticle Size, Charge, Encapsulation Efficiency, Purity, Morphology, Residual Solvent, Transition Temperature, Visual Inspections, le Microscopic.
Ntlafatso ea Tlhahiso ea Preclinical le lisampole
Lithuto tse ka khonehang le tse Felletseng, Nts'etsopele ea Sistimi ea Phano ea Lithethefatsi ea Nanoparticle (Preclinical Synthesis le Analytics), Ho kenyelletsa Ionizable le Cationic Lipid Nanoparticles hammoho le Polymeric le Hybrid Lipid Nanoparticles, Optimization, Characterization, Chefo, Katleho, Mekhoa ea Tlhahlobo, Mekhoa e Nyenyane ea Ho Etsa Lintho Theknoloji TransferPreclinical Formulation Synthesis, Optimization, Production Process, Litsamaiso tsa Phano ea Lithethefatsi le Nts'etsopele ea Nanomedicines
Ntlafatso ea Ts'ebetso ea Tlhahiso (GMP)
T&T Scientific E Fana ka Mefuta e sa Tšoaneng 'me Ha e le hantle Mekhoa eohle ea Tlhahiso e Sebelisitsoeng ho Etsa Lihlahisoa tsa Lithethefatsi tsa Nanoparticle tse kang Gene Therapies, le Vaccines. Ho Bolela. Tse 'maloa Mehato ena e kenyeletsa: Ethanol Injection kapa Solvent Injection, Thin Film Hydration, Extrusion, Homogenization, Microfluidics le Sonication (Bath, Tip le Continuous).
Ntlafatso ea Mekhoa ea Tlhahlobo (Phanele e Felletseng, Sebopeho, Tlaleho)
Ho T&T Scientific, Re fana ka Panel e Felletseng le e Feletseng ea cGMP Analytical Panel e Hlokehang bakeng sa Taolo ea Boleng ba Lihlahisoa tsa Lithethefatsi tsa Nanoparticle tse kang: Nanoparticle Size, Charge, Encapsulation Efficiency, Purity, Morphology, Residual Solvent, Transition Temperature, Visual Inspections, Targeting le Endosomal Thepa le Microscopic. Hape re Thehile Balekane Bakeng sa Liteko tsa Clinical le Lithuto tsa Liphoofolo.
cGMP Clinical and Commercial Batch Manufacturing, Tlatsa le Qetella
T&T Scientific E Felletse Ts'ebetso ea GMP Tlas'a Mohaho o le Mong 'me E hlahlobiloe ka Katleho Ka makhetlo a 5. Sistimi ea Tsamaiso ea Boleng ea T&T Scientific Corporation e nka tataiso ho tsoa ho 21 CFR Karolo ea 820 ea Melao ea Tsamaiso ea Boleng mme e latela litlhoko tsohle tsa taolo ea FDA GMP. Litlhoko tsena li kenyelletsa 21 CFR Karolo ea 210, 21 CFR Karolo ea 211, le 21 CFR Karolo ea 11. Khampani ha e tseka ho qheleloa ka thoko ho 21 CFR Karolo ea 820, 201, 211, 11 ho 7140 Regal Lane, Knoxville, TN 37918.
Theknoloji ea Tlhahiso ea Solvent Manufacturing
Solvent Ente Technologies Ke Ente ea Tharollo ea Lipid (Ka Ethanol Kapa Diethyl Ether) Ka Mekhahlelong e Metsi Ho Kenyelletsoa Lithethefatsi le Buffer. Mekhoa ea Ente ea Solvent e kenyelletsa ho qhibiliha ha Lipid ho Sehlahisoa sa Organic le ho Enteloa Tharollo Mokhahlelong oa Mokelikeli. Li-solvents tse peli tse ka sehloohong (Ethanol le Ether) li hiriloe molemong oa Tokiso ea Liposomal Nanoformulation. T&T Scientific E Fana ka Sethala se Molemohali sa Lefatše bakeng sa Scalable, GMP, Controlled and Precipe Production of Nanoparticle Drug Products ka Mohato o le Mong.
Liposome Extrusion Manufacturing Technologies
Liposome Extrusion Techniques li sebelisoa bakeng sa Sizing Lipid Nanoparticles ka ho nepahetseng, Liposomes, Lipoplexes, Niosomes le Lihlahisoa tse ling tsa Nano-scale Pharmaceutical Drug and Drug Delivery Systems. T&T Scientific E Fana ka Mokhoa oa Pele oa Lefatše oa Tšebeliso e le 'Ngoe ea Lipid le Liposome Extrusion System e Lumellang Tlhahiso e Potlakileng, e Bonolo, e sa Silafalang, le ea boleng bo holimo ea Lihlahisoa tsena tsa Lithethefatsi tsa Nanomedicine tse nang le PDI tse tlase ho 0.05-0.07
Sistimi ea Phano ea Lithethefatsi (Lipids, Polymer, Hybrids)
T&T Scientific e fana ka bobeli: 1) Lihlahisoa tse Itokiselitseng ho Sebelisa le Kits joalo ka Lipids, Polymers le Hybrid Nanoparticles 2) Tlas'a Nts'etsopele le Bohlokoa ba Nanoparticles e entsoeng ke Lipids (Cationic, Ionizable, le Neutral), Polymers, le Hybrid e Kenyelletsang Mefuta e sa tšoaneng ea Lipids le Polymers.
CDMO e kenyeletsang tsohle le Sethala sa Phetiso ea Theknoloji
bakeng sa Litsamaiso tsa Phano ea Lithethefatsi & Nanomedicines ho tloha Preclinical ho ea Commercial
Scalable Laboratory & E tsoela pele Theknoloji ea tlhahiso ea GMP
Fully Automated with Artificial Intelligence le Matla a ho Ithuta ka Mechini
CDMO e ngolisitsoeng ke FDA
ka Electronic cGMP Quality Management System Tumellano ka ho Feletseng Litaelo tsa Federale tsa 21 CFR Karolo ea 210, 211, le 11 ea Pharmaceutical Ntlafatso le Tlhahiso
Mekhoa ea Phaliso e Thehiloeng ka Lipid ho Nts'etsopele ea Liente tsa Liphatsa tsa lefutso le tsa Subunit
Bajari ba Lipidic ba entsoe ka thepa ea tlhaho, ea maiketsetso, kapa ea fisioloji ea lipid/phospholipid.
Ntlafatso ea maemo a polokelo bakeng sa liente tsa RNA tse ikatisang tsa lipid nanoparticle
E 'ngoe ea liteko tsa pele mabapi le phano ea limolek'hule tsa RNA e qalile ka 1978, ha li-lymphocyte tsa mouse li ne li fetisetsoa in vitro ka mRNA encoding rabbit globin e sebelisa liposomes.
mRNA e na le polelo e ikhethang le ea nakoana e fokotsang kotsi ea ho kenya mutagenesis. Ho tloha ha ho sibolloa ka in vitro transcribed mRNA, synthetic mRNA e fumane thahasello e kholo ho tsoa ho bo-ramahlale ba fapaneng ba baeloji, bongaka le saense ea lintho tse bonahalang.
Taylor Dispersion Analysis ho tšehetsa lipid-nanoparticle formulations bakeng sa liente tsa mRNA
Lipid nanoparticles (LNPs) hajoale ke litsamaiso tsa phepelo ea messenger ribonucleic acid (mRNA) tse tsoetseng pele ka ho fetesisa tse seng tsa kokoana-hloko.
Kabo ea litefiso le bokhoni ba mRNA lipid nanoparticles
Lipid nanoparticles (LNPs) ke likoloi tse sebetsang hantle tsa ho fana ka liente le litlhare tsa mRNA. Ho bile phephetso ho lekola litšobotsi tsa sephutheloana sa mRNA.....
Circle RNAs (circRNA) ke sehlopha sa tlhaho (biogenic) kapa synthetic e koetsoeng RNA ntle le 5′ kapa 3′ pheletso......
Kakaretso e felletseng ea vaerase ea oncolytic e sebelisang li-membrane tsa hybrid erythroctye-liposome bakeng sa katleho e eketsehileng ea anti-refractory tumor.
"Manahano a bohlokoa ho feta tsebo. Tsebo e lekanyelitsoe. Menahano e pota-potile lefats'e .... Ntho ea bohlokoa ke hore u se ke ua khaotsa ho botsa. Bohelehele bo na le lebaka la bona la ho ba teng .... Bophelo bo tšoana le ho palama baesekele. Ho boloka hao ho leka-lekana, u tlameha ho tsoela pele ho tsamaea .... Loanela hore u se ke ua atleha, empa ho e-na le hoo u be oa bohlokoa....."
Thomas Edison
Moqapi
"Le ka mohla u se ke ua nyahama ha u hlōleha. Ithute ho eona. Tsoela pele ho leka .... Ha kea hlōleha. Ke fumane litsela tse 10,000 tse ke keng tsa sebetsa .... Ho se phomole ke ho se khotsofale le ho se khotsofale ke tlhokahalo ea pele ea tsoelo-pele. . Mpontše monna ea khotsofetseng ka ho feletseng 'me ke tla u bontša ho hlōleha."
Bob Langer
MIT - Harvard
"Khothalletsa liithuti ho sebetsa mererong e nang le tšusumetso e phahameng e ka fetolang lefats'e. Le ka mohla u se ke ua re khopolo ena e ke ke ea sebetsa. Feela latela pelo ea hau. Khetha ntho eo u nahanang hore u tla e rata. Ke ne ke leka ho hlahisa polima ea ho lokolloa e laoloang le lintho li ne li sa sebetse hantle. Ho ne ho e-na le litsela tse makholo tsa ho nahana ka ho etsa sena ... Maikutlo a ka a nthusitse ho nkisa tseleng e sebetsang."
Steve Jobs
Apple
"Batho ba nahana hore ho tsepamisa mohopolo ho bolela ho lumela ntho eo u lokelang ho tsepamisa maikutlo ho eona .... Ho bolela ho hana likhopolo tse ling tse lekholo tse ntle tse teng. U tlameha ho khetha ka hloko. U se ke ua lumella lerata la ba bang." maikutlo a khantša lentsoe la hau le ka hare... Ka nako e 'ngoe bophelo bo u otla hloohong ka setene.U se ke ua lahleheloa ke tumelo..... Ha se tumelo ea theknoloji.Ke tumelo ho batho.
Jack Ma
Alibaba Group
"Haeba u sa tele, u ntse u e-na le monyetla. Ho tela ke ho hloleha ho hoholo. Ke hlōlehile lintho tse qabolang: tlhahlobo ea bohlokoa ea sekolo sa mathomo makhetlo a mabeli, ka makhetlo a mararo sekolong se mahareng, ke ile ka etsa kopo ea Harvard, ka makhetlo a 10. , ea hanoa, ke ile ka etsa kopo ea KFC ha e fihla Chaena.
Jeff Bezos
Amazon
"Haeba re ka boloka bahlolisani ba rona ba tsepamisitse maikutlo ho rona ha re ntse re tsepamisitse maikutlo ho moreki, qetellong re tla tsoa hantle .... Se kotsi ke ho se fetohe. Amazon ke sebaka se setle ka ho fetisisa lefatšeng sa ho hloleha .... sebaka se setle ka ho fetisisa lefatšeng sa ho hloleha le ho hloleha le boqapi ke mafahla a ke keng a arohana. bophelo ba k'hamphani."
Ho fetolela Novel Nanomedicines ho Impact ho tloha Lab ho ea ho Bakuli
Sebelisa metsu e letšehali / e nepahetseng ho tsamaea tseleng ea li-slides kapa sesepa ka ho le letšehali / ka ho le letona haeba u sebelisa mochine oa selefouno
Ho khetha khetho ho fella ka ho khatholla leqephe le felletseng.
Tobetsa konopo ea sebaka ebe u motsu linotlolo ho etsa khetho.
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