Sethala se Kenyellelitseng Tsohle sa Tlhahiso, Phetisetso ea Theknoloji, le Tlhahiso ea Preclinical ho cGMP Commercial: Theknoloji le Litšebeletso.
Sistimi ea Phano ea Lithethefatsi (Lipids, Polymers, Hybrids)
Re Theha Mefuta e sa tšoaneng ea Tšebelisano ka Sehlopha sa Rōna le Theknoloji, 'me re Etsa Lithuto tse Felletseng le Tse Kopanetsoeng Ho Kenyeletsoa Lipatlisiso Tse Etsang: Nts'etsopele ea Sistimi ea Phano ea Lithethefatsi ka li-API tse lakatsehang joalo ka mRNA, DNA, siRNA, Antibodies, Protein, Peptides le Limolek'hule Tse Nyenyane: Tlhabollo, le Litšebeletso tsa Teko, K'hamphani e Kopanetsoeng le Lintlafatso tse Tšehetsoeng ke 'Muso (ke hore, SBIR/STTR)
Tlhahlobo ea Analytical, Characterization, Assay Development
Teko e Felletseng ea Tlhahlobo ea Tloaelo (GMP le Non-GMP) le Mekhoa e ntlafalitsoeng bakeng sa Nts'etsopele ea Mehato ea Pele ea Lithethefatsi, Tlhahlobo ea Tlhahlobo, Nts'etsopele le Phetiso ea Theknoloji, Tsoelo-pele e Felletseng ea Tlhahlobo le Litlhahlobo tse kang: Nanoparticle Size, Charge, Encapsulation Efficiency, Purity, Morphology, Residual Solvent, Transition Temperature, Visual Inspections, le Microscopic.
Ntlafatso ea Tlhahiso ea Preclinical le lisampole
Lithuto tse ka khonehang le tse Felletseng, Nts'etsopele ea Sistimi ea Phano ea Lithethefatsi ea Nanoparticle (Preclinical Synthesis le Analytics), Ho kenyelletsa Ionizable le Cationic Lipid Nanoparticles hammoho le Polymeric le Hybrid Lipid Nanoparticles, Optimization, Characterization, Chefo, Katleho, Mekhoa ea Tlhahlobo, Mekhoa e Nyenyane ea Ho Etsa Lintho Theknoloji TransferPreclinical Formulation Synthesis, Optimization, Production Process, Litsamaiso tsa Phano ea Lithethefatsi le Nts'etsopele ea Nanomedicines
Ntlafatso ea Ts'ebetso ea Tlhahiso (GMP)
T&T Scientific E Fana ka Mefuta e sa Tšoaneng 'me Ha e le hantle Mekhoa eohle ea Tlhahiso e Sebelisitsoeng ho Etsa Lihlahisoa tsa Lithethefatsi tsa Nanoparticle tse kang Gene Therapies, le Vaccines. Ho Bolela. Tse 'maloa Mehato ena e kenyeletsa: Ethanol Injection kapa Solvent Injection, Thin Film Hydration, Extrusion, Homogenization, Microfluidics le Sonication (Bath, Tip le Continuous).
Ntlafatso ea Mekhoa ea Tlhahlobo (Phanele e Felletseng, Sebopeho, Tlaleho)
Ho T&T Scientific, Re fana ka Panel e Felletseng le e Feletseng ea cGMP Analytical Panel e Hlokehang bakeng sa Taolo ea Boleng ba Lihlahisoa tsa Lithethefatsi tsa Nanoparticle tse kang: Nanoparticle Size, Charge, Encapsulation Efficiency, Purity, Morphology, Residual Solvent, Transition Temperature, Visual Inspections, Targeting le Endosomal Thepa le Microscopic. Hape re Thehile Balekane Bakeng sa Liteko tsa Clinical le Lithuto tsa Liphoofolo.
cGMP Clinical and Commercial Batch Manufacturing, Tlatsa le Qetella
T&T Scientific E Felletse Ts'ebetso ea GMP Tlas'a Mohaho o le Mong 'me E hlahlobiloe ka Katleho Ka makhetlo a 5. Sistimi ea Tsamaiso ea Boleng ea T&T Scientific Corporation e nka tataiso ho tsoa ho 21 CFR Karolo ea 820 ea Melao ea Tsamaiso ea Boleng mme e latela litlhoko tsohle tsa taolo ea FDA GMP. Litlhoko tsena li kenyelletsa 21 CFR Karolo ea 210, 21 CFR Karolo ea 211, le 21 CFR Karolo ea 11. Khampani ha e tseka ho qheleloa ka thoko ho 21 CFR Karolo ea 820, 201, 211, 11 ho 7140 Regal Lane, Knoxville, TN 37918.
Theknoloji ea Tlhahiso ea Solvent Manufacturing
Solvent Ente Technologies Ke Ente ea Tharollo ea Lipid (Ka Ethanol Kapa Diethyl Ether) Ka Mekhahlelong e Metsi Ho Kenyelletsoa Lithethefatsi le Buffer. Mekhoa ea Ente ea Solvent e kenyelletsa ho qhibiliha ha Lipid ho Sehlahisoa sa Organic le ho Enteloa Tharollo Mokhahlelong oa Mokelikeli. Li-solvents tse peli tse ka sehloohong (Ethanol le Ether) li hiriloe molemong oa Tokiso ea Liposomal Nanoformulation. T&T Scientific E Fana ka Sethala se Molemohali sa Lefatše bakeng sa Scalable, GMP, Controlled and Precipe Production of Nanoparticle Drug Products ka Mohato o le Mong.
Liposome Extrusion Manufacturing Technologies
Liposome Extrusion Techniques li sebelisoa bakeng sa Sizing Lipid Nanoparticles ka ho nepahetseng, Liposomes, Lipoplexes, Niosomes le Lihlahisoa tse ling tsa Nano-scale Pharmaceutical Drug and Drug Delivery Systems. T&T Scientific E Fana ka Mokhoa oa Pele oa Lefatše oa Tšebeliso e le 'Ngoe ea Lipid le Liposome Extrusion System e Lumellang Tlhahiso e Potlakileng, e Bonolo, e sa Silafalang, le ea boleng bo holimo ea Lihlahisoa tsena tsa Lithethefatsi tsa Nanomedicine tse nang le PDI tse tlase ho 0.05-0.07
Sistimi ea Phano ea Lithethefatsi (Lipids, Polymer, Hybrids)
T&T Scientific e fana ka bobeli:
1) Lihlahisoa tse Itokiselitseng ho Sebelisa le Kits joalo ka Lipids, Polymers le Hybrid Nanoparticles
2) Tlas'a Nts'etsopele le Bohlokoa ba Nanoparticles e entsoeng ke Lipids (Cationic, Ionizable, le Neutral), Polymers, le Hybrid e Kenyelletsang Mefuta e sa tšoaneng ea Lipids le Polymers.
Ithute ka Lintlafatso tsa Morao-rao tse Amang Indasteri le Academia
Taylor Dispersion Analysis ho tšehetsa lipid-nanoparticle formulations bakeng sa liente tsa mRNA
Lipid nanoparticles (LNPs) hajoale ke litsamaiso tsa phepelo ea messenger ribonucleic acid (mRNA) tse tsoetseng pele ka ho fetesisa tse seng tsa kokoana-hloko.
Ithute haholoanyane
Kabo ea litefiso le bokhoni ba mRNA lipid nanoparticles
Lipid nanoparticles (LNPs) ke likoloi tse sebetsang hantle tsa ho fana ka liente le litlhare tsa mRNA. Ho bile phephetso ho lekola litšobotsi tsa sephutheloana sa mRNA.....
Ithute haholoanyane
Circular RNA: Moeli o hlahang ho sepheo sa kalafo sa RNA, therapeutics ea RNA, le liente tsa mRNA.
Circle RNAs (circRNA) ke sehlopha sa tlhaho (biogenic) kapa synthetic e koetsoeng RNA ntle le 5′ kapa 3′ pheletso......
Ithute haholoanyane
Ithute ka Lintlafatso tsa Morao-rao tse Amang Indasteri le Academia
Kakaretso e felletseng ea vaerase ea oncolytic e sebelisang li-membrane tsa hybrid erythroctye-liposome bakeng sa katleho e eketsehileng ea anti-refractory tumor.
Ho tsamaisoa ka methapo ea oncolytic virus (OVs) hoa ts'episa kalafong ea mofetše.
Ithute haholoanyane
Mekhoa ea tlhaho ea 'mele ea ho itšireletsa mafung ea liente tsa mRNA
Sethala sa lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA se sebelisitsoe ho hlahisa liente tse sireletsehileng le tse sebetsang ka nako e rekotiloeng khahlano le COVID-19.
Ithute haholoanyane
Ente e ikatisang ea RNA e sireletsa litoeba khahlanong le tšoaetso e bolaeang ea kokoana-hloko ea Ebola
Likokoana-hloko tse hlahang le tse hlahang hape, tse kang Zaire Ebola virus (EBOV), li baka tšokelo lefatšeng ka bophara 'me li hloka mehato ea hang-hang ea ho loantša....
Ithute haholoanyane
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